Henry Isaac (born 14 February 1980 in Owerri), formerly known as Henry Nwosu, is a Nigerian former footballer.
Isaac began his career in Iwuanyanwu Nationale. In 1998 he moved to Eintracht Frankfurt. He made his debut in the Bundesliga in 1998 against FC Schalke 04. After his time at Eintracht Frankfurt he played in the 2. Bundesliga with Waldhof Mannheim and FC St. Pauli.